Our Faculty
Sebastián Malleza, M.D.
Publications of Sebastián Malleza, M.D.
2025 in Review: FDA Approvals, Practice Guidelines, and Label Changes in Psychiatry
0.50 CMEs
This guide provides a comprehensive overview of 2025's key regulatory and guideline updates in psychiatry, covering new FDA approvals, label changes, and practice guidelines across depression, schizophrenia, addiction, neurocognitive disorders, and neurodevelopmental conditions, emphasizing practical implementation considerations for clinicians.
Serotonin Syndrome: Mechanisms, Diagnosis, High-Risk Interactions, and Management
1.00 CMEs
This guide provides a comprehensive review of serotonin syndrome, covering its pathophysiology, clinical presentation using Hunter Criteria, risk stratification of drug combinations, and severity-based management strategies including supportive care and cyproheptadine use.
Antidepressants and Metabolic Disturbances
0.50 CMEs
This guide examines antidepressant-induced weight gain mechanisms, risk stratification of medications (highest risk: mirtazapine, paroxetine, TCAs; lowest: bupropion, fluoxetine, vortioxetine), patient vulnerability factors, monitoring protocols, and management strategies including medication switching and adjunctive treatments.
Vilazodone: Pharmacology, Indications, Dosing Guidelines and Adverse Effects
0.50 CMEs
This guide provides a comprehensive overview of vilazodone, a dual-action SSRI with 5-HT1A partial agonist properties approved for major depressive disorder, detailing its pharmacology, clinical applications, dosing requirements with food, drug interactions, side effects, and positioning relative to standard antidepressants despite lacking proven superiority.
Initial Antidepressant Selection for Unipolar Depression: Translating Guidelines into Practice
0.50 CMEs
This guide presents a contemporary framework for selecting initial antidepressant therapy in Major Depressive Disorder, emphasizing personalized treatment matching based on symptom clusters, patient priorities, and comorbidities through shared decision-making and measurement-based care approaches.
Antidepressant-Induced Emotional Blunting: Diagnosis, Mechanisms and Management
0.50 CMEs
This guide explores antidepressant-induced emotional blunting (AIEB), a common side effect affecting 40-60% of patients on SSRIs/SNRIs. It covers clinical recognition, differentiation from depression, underlying serotonin-dopamine mechanisms, risk stratification across antidepressant classes, and evidence-based management strategies including dose reduction and switching options.
Dextromethorphan & Bupropion: Pharmacology, Indications, Dosing Guidelines and Adverse Effects
0.50 CMEs
This guide provides a comprehensive overview of dextromethorphan/bupropion, the first oral NMDA receptor antagonist approved for major depressive disorder, covering its unique mechanism, rapid onset benefits, dosing strategies, significant drug interactions via CYP2D6 inhibition, contraindications, and special considerations for various patient populations.
Ketamine Guide: Pharmacology, Indications, Dosing Guidelines and Adverse Effects
0.50 CMEs
This guide provides a comprehensive overview of ketamine for psychiatric use, covering its rapid antidepressant mechanisms, off-label applications in treatment-resistant depression and suicidality, dosing protocols, pharmacokinetics, drug interactions, adverse effects, and special population considerations.
Esketamine Guide: Pharmacology, Indications, Dosing Guidelines and Adverse Effects
0.50 CMEs
This guide provides a comprehensive overview of esketamine, a non-competitive NMDA receptor antagonist for treatment-resistant depression and major depression with suicidal ideation, covering its rapid onset of action, pharmacology, administration requirements, side effects, and risk management through the REMS program.
Mirtazapine Guide: Pharmacology, Indications, Dosing Guidelines and Adverse Effects
0.50 CMEs
This guide provides a comprehensive overview of mirtazapine, focusing on its unique pharmacological profile, clinical applications, and practical prescribing information. It covers the medication's receptor-binding properties, efficacy for depression with insomnia or poor appetite, dosing considerations, side effect management, and special population considerations.
Bupropion Guide: Pharmacology, Indications, Dosing Guidelines and Adverse Effects
0.50 CMEs
This guide provides a comprehensive overview of bupropion, covering its pharmacology as a norepinephrine-dopamine reuptake inhibitor, therapeutic applications for depression, smoking cessation, and seasonal affective disorder, along with dosing and formulation considerations, side effects, and use in special populations, including pregnancy and hepatic/renal impairment.
Vortioxetine Guide: Pharmacology, Indications, Dosing Guidelines and Adverse Effects
0.50 CMEs
This guide provides a comprehensive overview of vortioxetine, covering its pharmacology, FDA-approved indications, dosing strategies, side effects, drug interactions, and special considerations for specific patient populations including pregnancy and hepatic/renal impairment.
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