Unbiased and Practical Psychopharmacology Updates

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TRENDING IN PSYCHOPHARMACOLOGY INSTITUTE

Quick Takes

The latest research that matters to your practice. CME available.

Switching Oral Antipsychotics: Six Strategies and Tips

Benzodiazepine Tapering: Key Takeaways From New Guidelines

Deprescribing Antipsychotics Post-Delirium: Why It Matters

Is Ondansetron Effective for Negative Symptoms in Schizophrenia?

Lithium Orotate: Breakthrough Treatment for Alzheimer’s Disease?

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Brain Guides

Guides distilling the literature for confident prescribing. CME available.

Tricyclic Antidepressants in Psychiatry: Selection and Prescribing

Serotonin Syndrome: Mechanisms, Diagnosis, High-Risk Interactions, and Management

Antidepressants and Metabolic Disturbances

Gastrointestinal Side Effects of Antidepressants: Mechanisms, Comparison and Management Strategies

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Video Lectures

A selection of practical sections from our video lectures. CME available for Bronze, Silver, and Gold members.

Initiating and Optimizing Clozapine

Treating Anxiety Disorders in Patients With Cancer

Prevalence, Assessment, and Management of RBD

Considerations for Using Benzodiazepines and Benzodiazepine Receptor Agonists in the Geriatric Population

Use of Omega-3 Fatty Acids in Children and Adolescents

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RECENT PUBLICATIONS

Quick Take Vol. 87

0.50 CMEs
Which antipsychotic should you choose for a woman with first-episode psychosis? When clozapine isn’t an option for treatment-resistant schizophrenia, what actually works? Do real-world abuse data change how you select insomnia medications? Did serial ketamine outperform midazolam in a new inpatient trial? Can sustained anthocyanin intake improve cognition?
Faculty: Amanda Koire, M.D., Ph.D., Oliver Freudenreich, M.D., F.A.C.L.P., David A. Gorelick, M.D., Ph.D., D.L.F.A.P.A., F.A.S.A.M., James Phelps, M.D., Derick E. Vergne, M.D.
33.59 minutes in 5 audio sections

Dextromethorphan/Bupropion: Pharmacology, Indications, Dosing Guidelines and Adverse Effects

0.50 CMEs
This guide provides a comprehensive overview of dextromethorphan/bupropion — the first oral NMDA receptor antagonist approved for major depressive disorder and, as of April 2026, the first non-antipsychotic medication FDA-approved for agitation associated with dementia due to Alzheimer’s disease. It covers the unique mechanism and rapid antidepressant onset in MDD, the indication-specific titration schedules (including the slower titration with the new 30 mg/105 mg tablet for Alzheimer’s agitation), the supporting evidence, drug interactions driven by CYP2D6 inhibition, the newly added hyponatremia warning, and special considerations for elderly patients, CYP2D6 poor metabolizers, and other populations.
Sebastián Malleza, M.D.
Psychopharmacology Institute
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ADHD in Women: Estrogen Fluctuations, Stimulant Dosing, and Perimenopausal Cardiovascular Risk – Interview

0.50 CMEs
A discussion with Dr. Sandra Kooij on how estrogen fluctuations shape ADHD severity across the menstrual cycle, postpartum, and perimenopause in women. Topics include premenstrual stimulant dose adjustment, PMDD treatment options, postpartum depression risk, cardiovascular comorbidity, earlier menopause onset, and hormonal history taking.
Sandra Kooij, M.D., Ph.D.
Department of Psychiatry (Amsterdam UMC/VUmc) & PsyQ psycho-medical programs (The Hague, the Netherlands)
36.06 minutes of audio interview

Quick Take Vol. 86

0.75 CMEs
What are the teratogenic risks of zolpidem in pregnancy? Do SGLT2 inhibitors slow lithium-related kidney decline? Which antipsychotic works best for acute schizophrenia? Do herbals like Rhodiola or St. John’s wort help in mild depression? When should antipsychotics be continued after substance-induced psychosis?
Faculty: Amanda Koire, M.D., Ph.D., James Phelps, M.D., Oliver Freudenreich, M.D., F.A.C.L.P., Paul Zarkowski, M.D., David A. Gorelick, M.D., Ph.D., D.L.F.A.P.A., F.A.S.A.M.
42.09 minutes in 5 audio sections

PTSD Psychopharmacology Algorithm

1.50 CMEs
An updated algorithm for PTSD that prioritizes prazosin for sleep disturbances and nightmares before SSRIs. The presentation reviews evidence-based dosing for men and women, sleep initiation alternatives, second-line antidepressants, antipsychotics for PTSD-related psychosis, augmentation options, and considerations for comorbid substance use and bipolar disorder.
David Osser, M.D.
Harvard Medical School
83.49 minutes in 12 sections

Prescribing Tricyclic Antidepressants Safely: Drug Interactions, Side Effects, and Overdose

0.50 CMEs
This guide addresses tricyclic antidepressant safety across the prescribing lifecycle: CYP2D6 inhibitor interactions (fluoxetine, paroxetine, bupropion), CPIC-guided dosing in poor and ultrarapid metabolizers, a structured monitoring framework, agent selection across pregnancy, breastfeeding, and older adults, and overdose recognition.
Sebastián Malleza, M.D.
Psychopharmacology Institute
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CME Information

Physicians – CME Accreditation Statement

The activities below have been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Medical Academy LLC and the Psychopharmacology Institute. Medical Academy LLC is accredited by the ACCME to provide AMA PRA Category 1 Credits™ for physicians.

This CME program issues AMA PRA Category 1 Credit(s)™. Physicians should claim only credit commensurate with the extent of their participation in the activity.

Download Accreditation Information (PDF)

Nursing professionals – CME Accreditation Statement

The activities below have been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Medical Academy LLC and the Psychopharmacology Institute. Medical Academy LLC is accredited by the ACCME to provide AMA PRA Category 1 Credits™ for physicians.

This CME program issues AMA PRA Category 1 Credit(s)™. Physicians should claim only credit commensurate with the extent of their participation in the activity.

The ANCC accepts AMA PRA Category 1 Credit(s)™ as Contact Hours, under this calculation: 1 CME = 1 Contact Hour. 

Download Accreditation Information (PDF)

Physician assistants – CME Accreditation Statement

The activities below have been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Medical Academy LLC and the Psychopharmacology Institute. Medical Academy LLC is accredited by the ACCME to provide AMA PRA Category 1 Credits™ for physicians.

This CME program issues AMA PRA Category 1 Credit(s)™. Physicians should claim only credit commensurate with the extent of their participation in the activity.

Download Accreditation Information (PDF)

Self Assessment for MOC – Accreditation Statement
  • Psychopharmacology Institute Self-Assessment Program 2025

Dates: April 1, 2025 – April 1, 2028

The American Board of Psychiatry and Neurology has reviewed the Psychopharmacology Institute Self-Assessment Program 2025 and has approved this activity as part of a comprehensive Self-Assessment activity, which is mandated by the ABMS as a necessary component of Continuing Certification.

  • Psychopharmacology Institute Self-Assessment Program 2024

Dates: April 1, 2024 – April 1, 2027

The American Board of Psychiatry and Neurology has reviewed the Psychopharmacology Institute Self-Assessment Program 2024 and has approved this activity as part of a comprehensive Self-Assessment activity, which is mandated by the ABMS as a necessary component of Continuing Certification.

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