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Open Access Article

Antipsychotic Agents

Published on November 1, 2017 Expired on November 30, 2020

Flavio Guzmán, M.D.

Editor - Psychopharmacology Institute

Video presentations on antipsychotic agents

These are short video lectures highlighting the key clinical features of this class of drugs.

First vs Second-Generation Antipsychotics

A brief introduction to general concepts: definitions and differences between typical and atypical agents.

Antipsychotics for Schizophrenia: A Clinical Overview

The effects of antipsychotics on positive, negative and cognitive symptoms of schizophrenia. Antipsychotics for Bipolar Disorder The use of antipsychotic agents for the treatment of different phases of bipolar disorder: mania, depression and as maintenance treatment.

Mechanism of Action of AntipsychotIc Agents

An overview of the dopamine theory of schizophrenia, the effects of antipsychotics on dopamine pathways and other non-dopamine mechanisms.

Acute Neurological Adverse Effects of Antipsychotics

Summary of acute abnormal movements: akathisia, parkinsonism, dystonia.

Articles

First-Generation Antipsychotics

An introduction to the terminology, classification, effects on dopamine pathways and equivalences of typical agents.

Long-Acting Injectable Antipsychotics: A Practical Guide for Prescribers

This article summarizes the most clinically relevant features of long-acting injectable antipsychotics (LAIs, previously known as depot antipsychotics). We discuss general concepts as well as key prescribing facts of individual agents. The guide also includes two new formulations: aripiprazole lauroxil (Aristada) and 3-month paliperidone palmitate (Invega Trinza).

Interviews

Reviewing Antipsychotic Adverse Effects with Prof. Mark Taylor

Professor Mark Taylor is a consultant psychiatrist at the NHS in the UK. He is also Associate Professor at the University of Queensland in Brisbane Australia. He is the coauthor of a paper published in the Journal of Psychopharmacology: “First do no harm.” A systematic review of the prevalence and management of antipsychotic adverse effects”.

Second-Generation Antipsychotics (Atypicals)

This section includes mechanism of action, pharmacokinetics and indications of the most commonly prescribed antipsychotics.

Aripiprazole

Asenapine

Iloperidone

Lurasidone

Olanzapine

Quetiapine

Risperidone

Ziprasidone

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