Interview Highlights
- Augmentation of SSRI with dopaminergic or noradrenaline agents (such as bupropion or atypical antipsychotics) is effective.
- ECT is helpful for TRD, but it has a high relapse rate and high risk of cognitive impairment; continuation ECT may be more effective than antidepressant treatment.
- Ketamine nasal infusion, inflammatory markers, and genetic testing are all promising frontiers of psychiatry.
Text Version
Prof. Cowen is a professor of psychopharmacology at the Oxford University, where he specializes in research on the psychopharmacology of depression. Prof. Cowen’s expertise comes from both clinical experience and research in this area.
Dana Wang, M.D.: Prof. Cowen, how did your interest in treatment-resistant depression develop? Why did you pick this area of focus for your career?
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