05. What to Do if Clozapine Augmentation is Ineffective
Key Points
- After three failed antipsychotic trials including clozapine and augmentation, the probability of improvement with pharmacotherapy is low
- Some selected interventions that may be promising include:
- Stopping clozapine and trying aripiprazole
- Stopping clozapine and trying a combination of a first-generation antipsychotic + mirtazapine or a second-generation antipsychotic + celecoxib
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