Does Samidorphan Reduce Olanzapine-Induced Weight Gain?

Transcript

Hi! You’re listening to the Psychopharmacology Institute podcast. I’m your host, Dr. Wegdan Rashad and this is the show that aims to help you, the mental health clinician stay sharp on psychopharm!

Our episode today is about olanzapine-induced weight gain. It is estimated that between 22% and 80% of patients taking olanzapine will gain weight. So in an attempt to curb this, clinical research has been experimenting with mu-opioid receptor blockers like naltrexone and samidorphan for this purpose. Now, mu-opioid antagonists, work by suppressing the appetite for food, as far as we understand. So today, I am going to be featuring a Quick Take with Dr. Jim Phelps on a paper that discusses how efficacious samidorphan is for olanzapine-induced weight gain in patients with schizophrenia.

Alright, take it