03. The Glutamate System: Role in Depression
Key Points
- The glutamatergic system has critical functions throughout the brain and regulates synaptic plasticity.
- Abnormal levels of glutamate have been found in the cerebrospinal fluid, plasma, serum, and brain tissue of individuals with depression.
- Imaging studies have also reported abnormal glutamate as well as GABA levels or ratios in many key brain areas implicated in mood disorders.
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