02. The Failure of the Monoamine Deficiency Hypothesis of Depression
Key Points
- Despite many advances (including virtually all standard antidepressant treatments), the monoamine deficiency hypothesis of depression cannot fully explain the neurobiology of depression.
- This is best seen in the large number of individuals who do not respond to standard drugs based on the monoamine deficiency hypothesis (e.g., SSRIs, SNRIs, TCAs).
- This is also seen in the delay in the onset of response in humans: the full clinical effect of antidepressants is generally not experienced for at least 2 to 4 weeks following initiation of treatment.
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