Transcript
So let’s look at clinically relevant drug interactions. There are two drug interactions with lamotrigine that must be managed carefully, when you add it to divalproex and when it is used with carbamazepine. Many clinicians understand these issues but I will review them here in a moment. There is one other interaction that doesn’t require management but it gets inaccurate press coverage, so I will review that as well and that is oral contraceptives.
References
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- Perucca E. Clinically relevant drug interactions with antiepileptic drugs. Br J Clin Pharmacol . 2006 Mar;61(3):246–55.
- Christensen J, Petrenaite V, Atterman J, et al. Oral contraceptives induce lamotrigine metabolism: evidence from a double-blind, placebo-controlled trial. Epilepsia . 2007 Mar;48(3):484–9.
- Wegner I, Edelbroek PM, Bulk S, Lindhout D. Lamotrigine kinetics within the menstrual cycle, after menopause, and with oral contraceptives. Neurology . 2009 Oct 27;73(17):1388–93
- Lamictal Interactions
- Sidhu J, Job S, Singh S, Philipson R. The pharmacokinetic and pharmacodynamic consequences of the co-administration of lamotrigine and a combined oral contraceptive in healthy female subjects . Br J Clin Pharmacol. 2006 Feb;61(2):191–9.
