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This is an article I’m excited about. I think it has the potential for a major change in clinical practice, looking at “Lithium for the Treatment of Minimal Cognitive Impairment in an Attempt to Prevent Progression to Dementia.” The lead author of this article here is Orestes Forlenza. He is a psychiatric researcher at the University of Sao Paulo in Brazil. You may have seen his team’s 2011 randomized trial of low-dose lithium for the prevention of Alzheimer’s. That was groundbreaking, setting the stage for this current article, which is an expansion and an extension. Similar to cholesterol-lowering agents first tested in patients who were at high risk of myocardial infarction, Dr. Forlenza, and his colleagues studied patients with minimal cognitive impairment because many of them were already on their way toward dementia. However, could the addition of lithium slow that course?
So, the concern is lithium in the elderly.
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