Transcript
Our next topic, how much risk of bleeding do SSRIs pose?
A recent meta-analysis concluded that the overall bleeding risk is increased at least a third but with a fairly wide range based on the review of a large number of studies. So we’re going to talk about four different types of bleeding risk and what we know to date regarding SSRIs. Do SSRIs increase the risk for gastrointestinal bleeding, perioperative bleeding, postpartum bleeding and cerebral bleeding or hemorrhagic stroke?
References
- Jiang, H. Y., Chen, H. Z., Hu, X. J., Yu, Z. H., Yang, W., Deng, M., … & Ruan, B. (2015). Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal bleeding: a systematic review and meta-analysis . Clinical Gastroenterology and Hepatology, 13(1), 42-50.
- Anglin, R., Yuan, Y., et al (2014). Risk of upper gastrointestinal bleeding with selective serotonin reuptake inhibitors with or without concurrent nonsteroidal anti-inflammatory use: a systematic review and meta-analysis . The American journal of gastroenterology, 109(6), 811-819.
- Oka, Y., Okamoto, K., Kawashita, N., Shirakuni, Y., & Takagi, T. (2014). Meta-analysis of the risk of upper gastrointestinal hemorrhage with combination therapy of selective serotonin reuptake inhibitors and non-steroidal anti-inflammatory drugs . Biological and Pharmaceutical Bulletin, 37(6), 947-953.
- Cheng, Y. L., et al (2015). Use of SSRI, but not SNRI, increased upper and lower gastrointestinal bleeding: a nationwide population-based cohort study in Taiwan . Medicine, 94(46).
- Quinn, G. R., Singer, D. E.,et al (2014). Effect of selective serotonin reuptake inhibitors on bleeding risk in patients with atrial fibrillation taking warfarin . The American journal of cardiology, 114(4), 583-586.
- Wallerstedt, S. M., Gleerup, H., et al (2009). Risk of clinically relevant bleeding in warfarin‐treated patients—influence of SSRI treatment . Pharmacoepidemiology and drug safety, 18(5), 412-416.
- Samuel, N. G., & Seifert, C. F. (2017). Risk of Bleeding in Patients on Full-Dose Enoxaparin With Venous Thromboembolism and Selective Serotonin Reuptake Inhibitors . Annals of Pharmacotherapy, 51(3), 226-231.
