03. The Role of Serotonin (5-HT) in Depression and Mood
Key Points
- The tryptophan depletion technique acutely reduces the availability of precursor for the production of 5-HT
- This leads to a worsening of mood in people who have recovered from depression
- 5-HT depletion profoundly undermines the therapeutic effect of SSRIs
- The action of 5-HT depletion to restore depressive thoughts is proof that depression leaves an enduring impact in the brain, that some call a “scar”
- This could explain why once someone has had a single episode of depression they are much more prone to have further ones
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