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Here’s an article that might directly change your treatment of patients with schizophrenia—if you believe the results. The intervention, which is vitamin D supplementation, is relatively innocuous and might have additional benefits, but it adds another pill to your patient’s daily regimen, and the broader data are mixed so far.
Hi! Jim Phelps here for the Psychopharmacology Institute. Here’s the backstory. There’s a whole body of research suggesting that vitamin D may regulate brain plasticity. The mechanism is via perineuronal nets. You may be familiar with that term; I wasn’t.
So, first, let’s take a moment to review perineuronal nets. An emerging concept in neuroscience is that brain plasticity is dependent not only on neurons and glial cells but also on what is present outside of these cells, the extracellular matrix. A specific form of the extracellular matrix is the perineuronal net, a lattice-like structure that connects neurons across synapses,
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