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Surely you’ve figured out that once-daily dosing of a medication leads to better adherence than twice daily and that 3 times a day dosing—well, you’d only consider that on an inpatient unit where the staff is keeping track of everything. But does twice-daily dosing potentially help with tolerability? Would fewer patients quit your medication if they only have to take half as much at once?
Hi! Jim Phelps here for the Psychopharmacology Institute. Here’s a meta-analysis of study discontinuation and adverse events data from 32 medication trials where comparisons could be made between once-daily and multiple doses per day for everything from antidepressants to antipsychotics. Isn’t that a nifty idea?
First, we’ll look at side effects and then efficacy. For side effects, there was no difference between once-daily and twice-daily dosing. The result is the same whether you look at study discontinuation, meaning any reason for dropping out, or at
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