Section - CAP Smart Takes

05. Pediatric Pharmacogenomic Profiling in the Emergency Department

Published on July 1, 2023 Certification expiration date: July 1, 2026

David R. Rosenberg, M.D.

Chair of the Department of Psychiatry & Behavioral Neuroscience - Wayne State University School of Medicine

Key Points

Combinatorial pharmacogenomic testing shows promise in guiding psychotropic medication selection for pediatric patients, improving therapeutic response, and reducing side effects.
Pediatric patients with depression or suicidal ideation may benefit from determining medication congruency through combinatorial pharmacogenomic testing, leading to better clinical outcomes.

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Hi! David Rosenberg here for the Psychopharmacology Institute. In this CAP—or Child and Adolescent Psychiatry—Smart Take, we will closely examine the pharmacogenomic profiling of pediatric patients on psychotropic medications presenting in an emergency department in an acute behavioral crisis. This is such a highly complex area, but it is fascinating. I believe this is where the field is going and needs to go. We are not there yet, but this has the chance to be a game changer and to advance our ability to more effectively prescribe, monitor, and treat pediatric patients with childhood-onset neuropsychiatric disorders. This type of work has the potential to guide individualized and personalized medication choices and enhance the likelihood of good therapeutic response, tolerability, and decreased side effects. Pharmacogenomic testing is becoming increasingly common in guiding medication side effects. Some facilities are routinely getting this testing for adult patients. It is increasingly being recognized that

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Learning Objectives:

Evaluate the evidence supporting the use of NAC in reducing alcohol use in adolescents.
Understand the potential role of metformin in managing weight gain associated with second-generation antipsychotic treatment in youth.
Recognize the challenges and dilemmas clinicians face when treating youth with ADHD and co-occurring cannabis use, considering the risks and benefits of different treatment approaches.
Evaluate the effectiveness and duration of action of amphetamine extended-release oral suspension in providing sustained symptom control throughout the day in youth with ADHD.
Understand the potential of pharmacogenomic profiling in guiding medication choices for pediatric patients with psychiatric disorders.

Original Release Date: July 1, 2023

Review and Re-release Date: March 1, 2024

Expiration Date: July 1, 2026

Expert: David Rosenberg, M.D.

Relevant Financial Disclosures:

None of the faculty, planners, and reviewers for this educational activity have relevant financial relationships to disclose during the last 24 months with ineligible companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

Contact Information: For questions regarding the content or access to this activity, contact us at support@psychopharmacologyinstitute.com

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Participants must complete the activity online during the valid credit period that is noted above.

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Accreditation Statement

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education through the joint providership of Medical Academy LLC and the Psychopharmacology Institute. Medical Academy is accredited by the ACCME to provide continuing medical education for physicians

Credit Designation Statement

Medical Academy designates this enduring activity for a maximum of 0.5 AMA PRA Category 1 credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.