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For our next Quick Take, let’s look at a new study just appearing in the current American Journal of Psychiatry advanced publication in March 2019 on a compound called samidorphan. It’s a mu-opioid receptor blocker. And here, we’re looking at whether or not adding it for patients who are taking olanzapine and experiencing weight gain can attenuate or reverse that weight gain relative to placebo. You’ve used plenty of olanzapine, surely, and so, just as surely, you’ve seen people gaining weight on it. The background data suggest that rate is somewhere between 22% and 68% or 80%—something like that. It’s huge. In this study, it was 65%. So, amongst those patients in that 65% group who are gaining weight, they were randomized to receive placebo or varying doses of samidorphan in this phase 2 clinical trial.
Just in case samidorphan is not familiar to you—it wasn’t to me—so, let’s back
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