04. Lamotrigine in Unipolar Depression, Efficacy vs Tolerability
Key Points
- A subset of patients with apparently unipolar depression might benefit from lamotrigine therapy, those with:
- more treatment resistance
- comorbid anxiety
- borderline personality disorder traits
- Unlike academics, patients often weight tolerability far above efficacy
- When viewed in that light, lamotrigine rockets to the top of the list of options for bipolar depression
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