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03. GAD Pharmacotherapy: Addressing Comorbidities and Special Populations

Published on May 23, 2018 Expired on April 1, 2021

David Osser, M.D.

Associate Professor of Psychiatry - Harvard Medical School

Key Points

  • Usually, insomnia is a symptom, not a disease
    • Consider differential diagnosis in GAD patients and treat accordingly
  • Avoid benzodiazepines in patients with anxiety who are substance abusers
  • Avoid antidepressants in bipolar patients with anxiety
  • In patients with comorbid PTSD and GAD, use prazosin added to antidepressants for PTSD-related sleep disturbances, daytime hyperarousal and irritability symptoms 

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Transcript

The first one we’re going to discuss is sleep disturbance or insomnia which is a common problem in people with GAD. There are multiple causes of insomnia. You can’t just assume it’s part of the GAD. Some of the treatments that we have actually worsen insomnia. So that may lead you to want to skip those options and consider other ones. For example, SSRIs and SNRIs generally are not effective for insomnia and may make it worse. Some 10% to 20% of patients given those products can have worsened or new onset of insomnia as a side effect.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Key Points

The key points probably are as follows. That insomnia is a symptom. It’s not a disease usually. So you have to consider the differential diagnoses in your GAD patients and treat accordingly. A second key point, avoid benzodiazepines in patients with anxiety who are substance abusers. Next, avoid antidepressants in bipolar patients with anxiety. And the final bullet point then on summarizing this node 2 is to use prazosin for PTSD-related sleep problems and daytime hyperarousal and irritability added to the antidepressants they’re on for their GAD for this comorbidity.

 

References

  1. Holsboer-Trachsler E, Prieto R. Effects of pregabalin on sleep in generalized anxiety disorder . Int J europsychopharmacol 2013;16:925–36.
  2. (Kaynak 2004, Nierenberg 1994) (Pollack 2008, Walsh 2007)
  3. Benitez et al., Use of benzodiazepines and selective serotonin reuptake inhibitors in middle-aged and older adults with anxiety disorders: A longitudinal and prospective study . Am J Geriat Psychiatry 2008;16:5-13.
  4. Berger et al., Magnitude of potentially inappropriate prescribing in Germany among older patients with generalized anxiety disorder . BMC Geriatr 2009;9:31.
  5. Montgomery, S., Chatamra, K., Pauer, L., Whalen, E., & Baldinetti, F. (2008). Efficacy and safety of pregabalin in elderly people with generalised anxiety disorder . The British Journal of Psychiatry, 193(5), 389-394.
  6. Reefhuis J et al. Specific SSRIs and birth defects: Bayesian analysis to interpret new data in the context of previous reports . BMJ 2015:351;h3190
  7. Kessler RC et al., The epidemiology of co-occurring addictive and mental disorders: Implications for prevention and service utilization . Am J Orthopsychiatry 1996:66:17-31.
  8. Fava M et al. Difference in treatment outcome in outpatients with anxious versus non-anxious depression: A STAR*D report . Am J Psychiatry 2008;165:342-51.
  9. Abejuela, H.R. and Osser, D.N., 2016. The Psychopharmacology Algorithm Project at the Harvard South Shore Program: an algorithm for generalized anxiety disorder .
  10. Harvard review of psychiatry, 24(4), pp.243-256.
  11. Leverich GS, et al. Risk of switch in mood polarity to hypomania and mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers . Am J Psychiatry 2006;163:232-9.
  12. Pacchiarotti et al. The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders . Am J Psychiatry 2013; 170:1249-62.
  13. Gao, K., Wu, R., Kemp, D.E., Chen, J., Karberg, E., Conroy, C., Chan, P., Ren, M., Serrano, M.B., Ganocy, S.J. and Calabrese, J.R., 2014. Efficacy and safety of quetiapine-XR as monotherapy or adjunctive therapy to a mood stabilizer in acute bipolar depression with generalized anxiety disorder and other comorbidities: a randomized, placebo-controlled trial . The Journal of clinical psychiatry, 75(10), pp.1062-1068.
  14. Bajor, L. A., Ticlea, A. N., & Osser, D. N. (2011). The Psychopharmacology Algorithm Project at the Harvard South Shore Program: an update on posttraumatic stress disorder . Harvard review of psychiatry, 19(5), 240-258.
  15. Raskind, M. A., Peterson, K., Williams, T., Hoff, D. J., Hart, K., Holmes, H., … & Millard, S. P. (2013). A trial of prazosin for combat trauma PTSD with nightmares in active-duty soldiers returned from Iraq and Afghanistan . American Journal of Psychiatry, 170(9), 1003-1010.

Learning Objectives:

After completing this activity, the learner will be able to:

  1. Apply an evidence-based algorithm for the treatment of generalized anxiety disorder

Original Release Date: 05/23/2018

Expiration Date: 04/01/2021

Relevant Financial Disclosures:

The following planners, faculty, and reviewers have the following relevant financial relationships with commercial interests to disclose:

Dr. Osser has disclosed the following relationships:

  • CreateSpace Publishers: Author of Psychopharmacology: A Concise Overview for Students and Clinicians, 2nd edition 2015

All of the relevant financial relationships listed for these individuals have been mitigated.

Contact Information: For questions regarding the content or access to this activity, contact us at support@psychopharmacologyinstitute.com

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