11. Experimental Treatments: Ketamine
Key Points
- Ketamine (an NMDA antagonist) is associated with a fast but transient antidepressant response in treatment-resistant patients
- Ketamine forms that are safer and able to overcome the transient effect limitation are being studied in clinical trials
- Ketamine’s mechanism of action could be linked to the metabolite hydroxynorketamine and its activity on glutamate AMPA receptors
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