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For our next research Quick Take, let’s look at neutropenia when patients are given clozapine.
Back in 2012, in a review, the schizophrenia researcher Herb Meltzer reported that only 10% to 20% of patients who are eligible for clozapine actually get it. But you can see why when you start looking at the risks, particularly the famous one: Neutropenia. For a new perspective on that, let’s look at a meta-analysis that was just completed from Adelaide in Australia. The lead authors, Hannah and Nicholas Myles, and their colleagues dredged the literature and found 108 studies on neutropenia in clozapine to get a sense of how common a problem this is. All the patients taken together yielded 450,000 patients over 3 decades. So, we really have a hawk’s-eye view here of the problem of neutropenia with the use of clozapine.
The rates that they found were divided into mild neutropenia, with
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