05. Augmentation With Second-Generation Antipsychotics
Key Points
- Second-generation antipsychotic augmentation:
- Effective strategy
- High burden of side effects
- Quetiapine
- Target symptoms: anxiety and sleeping difficulties
- Side effects: sedation and weight gain
- Aripiprazole
- Target symptoms: anhedonia, reduced motivation
- Side effects: movement disorders and anxiety
- When to augment versus switch?
- Augmentation is favored in partial responders to antidepressant treatment
- The addition of an SGA allows the initial response to be maintained
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