Section Free - Video Lectures

03. Antipsychotics for Agitation: Differences Between Tablets, Orally Disintegrating Tablets and Sublingual Formulations

Published on November 1, 2017 Expired on April 1, 2021

Michael D. Jibson, M.D., Ph.D.

Professor of Psychiatry - University of Michigan

Key Points

Orally disintegrating medications:
- Require a lower level of cooperation
- Are NOT more rapid than standard oral formulations
- Aripiprazole (Abilify Discmelt): 10-15 mg q 2 hrs, olanzapine (Zyprexa Zydis) 5-10 mg q 30 min - 2 hrs, risperidone (Risperdal M-tabs) 1-2 mg q 30 min
Sublingual asenapine:
- Not absorbed if swallowed, requires higher level of cooperation
- Dose range: 5-10 mg BID

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References

Wilson MP, et al. The Psychopharmacology of Agitation: Consensus Statement of the American Association for Emergency Psychiatry Project BETA Psychopharmacology Workgroup , West J Emerg Med (2012) 13: 26; https://doi.org/10.5811/westjem.2011.9.6866.
Haloperidol Drug Information. In: UpToDate, Sokol N (Ed), UpToDate, Waltham, MA; 2017. Available at https://www.uptodate.com/contents/haloperidol-drug-information
Abilify (aripiprazole) [package insert]. Otsuka America Pharmaceutical, Inc . Available online at https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021436s038,021713s030,021729s022,021866s023lbl.pdf
Saphris (asenapine) [package insert]. Actavis, Inc. 2017. Available online at http://pi.actavis.com/data_stream.asp?product_group=1908&p=pi&language=E.
Zyprexa (olanzapine) [prescribing information]. Indianapolis, IN: Lilly USA LLC; 2017 . Available at http://pi.lilly.com/us/zyprexa-pi.pdf
Risperdal (risperidone) [package insert]. Janssen Pharmaceuticals, Inc. 2017 . Available online at http://www.janssen.com/us/sites/www_janssen_com_usa/files/products-documents/risperdal-prescribing-information.pdf

Next Section

04. Injectable Antipsychotics: Formulations and Practical Strategies