01. The Role of Long-Acting Injectable Antipsychotics
Key Points
- LAIs can enable you to give an adequate trial to determine effectiveness in a poorly- or questionably-adherent patient
- If two adequate trials are ineffective: clozapine
- LAIs can enable more efficient progress through the two trials and get to clozapine sooner
- LAIs are no better than oral antipsychotics and ineffective for outpatients with inadequate structure or no family members to encourage adherence
- Use LAIs for patients who are excellent responders to oral antipsychotics but who are moderately poorly adherent
- Don’t settle for LAIs when response is suboptimal and clozapine could do better
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