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Category: Antidepressants

The Psychopharmacology of Fluoxetine: An Illustrated Review for Prescribers

The Psychopharmacology of Fluoxetine: An Illustrated Review for Prescribers

Author: Flavio Guzman, MD Fluoxetine has activating properties that make it a good option for patients with retarded depression or atypical depression. However, we should avoid activation in patients with insomnia and agitation. There is something that makes fluoxetine unique: its long half-life, we will discuss the advantages and disadvantages of this in clinical practice.… Continue Reading

Reviewing Bupropion for Depression: An Update with Dr. Derek Tracy

In this episode we interview Dr. Derek Tracy on the use of bupropion for depression. Dr. Tracy is a Consultant Psychiatrist and the Associate Clinical Director for Crisis, Inpatient, and Rehabilitation services at Oxleas NHS Foundation Trust, London. He is a BRC research fellow and the neuromodulation lead at the Institute of Psychiatry, Psychology, and Neuroscience, King’s… Continue Reading

The Psychopharmacology of Paroxetine: An Illustrated Summary for Prescribers

The Psychopharmacology of Paroxetine: An Illustrated Summary for Prescribers

Author: Flavio Guzman, MD Paroxetine (Paxil, Seroxat, Aropax) is an SSRI approved for major depressive disorder and most anxiety disorders. In clinical practice, many clinicians use it for patients with anxious depression. However, this observation hasn’t been specifically studied in randomized controlled trials. Regarding its side effects profile, important features include higher risk for sexual… Continue Reading

Pharmacotherapy of Treatment-Resistant OCD: Augmentation Strategies

Pharmacotherapy of Treatment-Resistant OCD: Augmentation Strategies

Treatment of obsessive compulsive disorder is often challenging. Treatment resistance is quite common, between 40 to 60% of patients do not show and adequate response to first-line treatments. We invited Dr. David Veale to comment on his meta-analysis published in BMC Psychiatry : “Atypical antipsychotic augmentation in SSRI treatment refractory obsessive-compulsive disorder: a systematic review… Continue Reading

Side Effects of Antidepressants: Interview with Dr. Rajnish Mago

In this expert interview we discuss side effects of antidepressants. Our guest today is Dr. Rajnish Mago. Dr. Mago currently serves as Director of the Mood Disorders Program at the Thomas Jefferson University Hospital in Philadelphia, Pennsylvania. He is Associate Professor of Psychiatry at the Jefferson Medical College. He recently published the high-yield book “Side… Continue Reading

Citalopram and Escitalopram: A Summary of Key Differences and Similarities

Citalopram and Escitalopram: A Summary of Key Differences and Similarities

Author: Flavio Guzman, MD Psychiatrist Pharmacology Department University of Mendoza Argentina Citalopram (Celexa) and escitalopram (Lexapro) are two commonly prescribed SSRIs used for the treatment of depression and anxiety disorders. This brief multimedia tutorial explores the differences and similiarities between these two SSRIs. Introduction: Basic Concepts Let me highlight some useful points before getting into more… Continue Reading

Venlafaxine and Desvenlafaxine: Differences and Similarities

Venlafaxine and Desvenlafaxine: Differences and Similarities

Author: Flavio Guzman, MD Venlafaxine (Effexor) is an SNRI that is metabolized to O-desmethylvenlafaxine or desvenlafaxine. In 2008 this active metabolite was approved as antidepressant (Pristiq). In this multimedia tutorial we discuss what the two drugs have in common and their differences, we also explore mechanisms of action, indications, pharmacokinetics, adverse effects and dosing guidelines.… Continue Reading

Antidepressants and Weight Change: An Evidence-Based Tool

Dent et al [1] conducted a systematic synthesis of the literature to rank the effect of psychotropic drugs on weight change. We summarize and reproduce some of their findings for antidepressant medications. Some key points include: Paroxetine and mirtazapine rank in the first two positions of drug-induced weight gain Tricyclic antidepressants and MAOIs are associated… Continue Reading

Free Course: “SSRIs: The Essentials”

Fluoxetine

Learn the essentials of SSRIs with our free online course.

One module per week:

  • The Mechanism of Action of SSRIs
  • Fluoxetine
  • Fluvoxamine
  • Paroxetine
  • Sertraline
  • Citalopram and Escitalopram
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