The Basics of Treatment-Resistant Depression

Treatment-Resistant Depression: An Interview with Dr. Prakash Masand

In this audio interview I discuss with Dr. Prakash Masand key concepts about treatment-resistant depression.

These include:

  • Definitions of treatment-resistant depression.
  • The concept of pseudoresistance in treatment-resistant depression: some considerations to keep in mind before labeling a patient as “treatment-resistant”.
  • The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study:
    • Its strenghts and weaknesses
    • Its implications for clinical practice
  • When to switch or augment antidepressants.
  • Evidence base for augmentation strategies: second generation antipsychotics, lithium, T3, lisdexamfetamine, modafinil, methylphenidate, folate and CBT.
  • How long should augmentation therapy be continued in MDD after remission.
  • When to use MAOIs.

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