The Basics of Treatment-Resistant Depression
In this audio interview I discuss with Dr. Prakash Masand key concepts about treatment-resistant depression.
- Definitions of treatment-resistant depression.
- The concept of pseudoresistance in treatment-resistant depression: some considerations to keep in mind before labeling a patient as “treatment-resistant”.
- The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study:
- Its strenghts and weaknesses
- Its implications for clinical practice
- When to switch or augment antidepressants.
- Evidence base for augmentation strategies: second generation antipsychotics, lithium, T3, lisdexamfetamine, modafinil, methylphenidate, folate and CBT.
- How long should augmentation therapy be continued in MDD after remission.
- When to use MAOIs.
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