Ziprasidone

FDA Warning: Ziprasidone Associated with DRESS Syndrome

The FDA has issued a warning (December 11, 2014) that the second generation antipsychotic ziprasidone (Geodon and others) is associated with a rare but serious skin condition known as Drug Reaction with Eosinophilia (DRESS)and Systemic Symptoms . Excerpts from the FDA website: A new warning has been added to the Geodon drug label to describe…

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Ziprasidone Adverse Effects

Source: Drug labeling information submitted to the Food and Drug Administration (FDA), updated by the National Library of Medicine (NLM). Commonly observed adverse reactions (incidence ≥5% and at least twice the incidence for placebo) were: Schizophrenia: Somnolence, respiratory tract infection. Manic and Mixed Episodes Associated with Bipolar Disorder: Somnolence, extrapyramidal symptoms, dizziness, akathisia, abnormal vision,…

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Ziprasidone (Geodon) Pharmacokinetics

Source: Drug labeling information submitted to the Food and Drug Administration (FDA), updated by the National Library of Medicine (NLM). Oral Pharmacokinetics Ziprasidone’s activity is primarily due to the parent drug. The multiple-dose pharmacokinetics of ziprasidone are dose-proportional within the proposed clinical dose range, and ziprasidone accumulation is predictable with multiple dosing. Elimination of ziprasidone…

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Mechanism of Action and Pharmacodynamics of Ziprasidone

By: Flavio Guzman, MD Mechanism of Action The mechanism of action of ziprasidone, as with other drugs having efficacy in schizophrenia, is unknown. However, it has been proposed that this drug’s efficacy in schizophrenia is mediated through a combination of dopamine type 2 (D2) and serotonin type 2 (5HT2) antagonism. As with other drugs having…

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Ziprasidone (Geodon) Indications: FDA-Approved Uses

Source: Drug labeling information submitted to the Food and Drug Administration (FDA), updated by the National Library of Medicine (NLM). Indications and Usage GEODON is an atypical antipsychotic. In choosing among treatments, prescribers should be aware of the capacity of GEODON to prolong the QT interval and may consider the use of other drugs first.…

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