Antidepressant Discontinuation Syndrome: Diagnosis, Prevention and Management

Author: Flavio Guzman, MD Discontinuation symptoms can occur with all antidepressant classes, and you will see many articles referring to SSRI discontinuation syndrome. The reason is that SSRIs are by far the most commonly prescribed antidepressant class. This syndrome consists of usually mild and reversible symptoms that can be grouped into six categories. As a…

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Venlafaxine and Desvenlafaxine: Differences and Similarities

Author: Flavio Guzman, MD Venlafaxine (Effexor) is an SNRI that is metabolized to O-desmethylvenlafaxine or desvenlafaxine. In 2008 this active metabolite was approved as antidepressant (Pristiq). In this multimedia tutorial we discuss what the two drugs have in common and their differences, we also explore mechanisms of action, indications, pharmacokinetics, adverse effects and dosing guidelines.…

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