Sleep & Insomnia

Psychopharmacology of Sleep and Wakefulness: Understanding Neurotransmitters and Pathways in Clinical Practice

Author: Flavio Guzman, MD This tutorial integrates neurotransmitters involved in sleep and arousal with the pharmacology of specific psychotropic agents. We review neurotransmitters that promote wakefulness (dopamine, norepinephrine, serotonin, acetylcholine, histamine, orexin/hypocretin) and summarize how current drugs influence each system. We also discuss neurotransmitters that promote sleep (adenosine, GABA, melatonin). This is an integration between…

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