Adverse Effects of SSRIs
Author: Flavio Guzman, MD
The video below is a brief (length 2:30) overview on the adverse effects of SSRIs.
- General concepts
- Gastrointestinal side effects
- CNS adverse effects:
- Basal ganglia
- Mental effects
- Sexual dysfunction
In this short video I’m going to review adverse effects of selective serotonin reuptake inhibitors.
I´ll start reviewing some facts about SSRI therapy.
The first one is that patients tolerate the SSRIs better than tricyclic antidepressants.
Most side effects are acute. They tend to diminish over days and weeks.
And these side effects include nausea, diarrhea, cramping, heartburn, and other symptoms of GI distress.
We’re going to classify side effects according to the system they affect:
First we are going to review gastrointestinal side effects. Then central nervous system side effects and finally sexual dysfunction induced by SSRIs.
Effects on the GI tract are mediated stimulation of serotonin 3 and 4 receptors. This stimulation can lead to increased GI motility, GI cramps. If the increase in GI motility is severe enough this can lead to diarrhea.
– Psychomotor retardation
– Distonic movements.
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