A video on Mu, Delta, Kappa and ORL1 receptors
By Flavio Guzmán, MD
This lecture discusses the following topics:
- General classification
- Cellular actions of opioid receptors
- Anatomical distribution and physiologic effects of mu, delta and kappa receptors
- Agonists and antagonists
- ORL-1 receptors
Part 1: Classification and cellular actions
Provides an introduction to the classification of opioid receptors, it also discusses the cellular effects of opioid receptor activation (presynaptic inhibition of neurotransmitter release).
Part 2: Mu, kappa and delta receptors (including agonists and antagonists)
Part 2 lists the most relevant agonists and antagonists for the different subtypes of opioid receptor, then effects upon activation (opioid physiology) are reviewed.
Part 3: ORL1, nociceptin or orphanin FQ receptor
Part 3 is an overview on the recently discovered ORL1 receptor.
If you prefer to review the figures at your own pace you can review the PPT slide by slide:
References and further reading
Katzung, B. Basic and Clinical Pharmacology. 11th ed. McGraw Hill Medical, 2009
Koneru A, Sreemantula S, Rizwan. Endogenous Opioids: Their Physiological Role and Receptors. Global J. Pharmacol., 3 (3): 149-153, 2009
McDonald J, Lambert DJ. Opioid Receptors. Continuing Education in Anaesthesia, Critical Care & Pain 2005 5:1
Trescot A, Sukdeb D. Opioid Pharmacology. Pain Physician 2008; 11:S133-S153
PDF: LAI Antipsychotics
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- New formulations (Aristada, Invega Trinza)
- Practical dosing tables