Bipolar Disorder

Lithium’s Mechanism of Action: An Illustrated Review

Author: Flavio Guzman, MD Lithium’s mechanism involves multiple levels of action, from macroscopic neuroprotective effects to intracellular changes. This tutorial discusses: Brain abnormalities found in patients suffering from bipolar disorder How lithium modulates dopamine, glutamate and GABA Intracellular changes associated with lithium use (effects on proteins such as PKC, MARCKS, GSK-3, IPPase and IMPase) Unravelling…

Read More

Bipolar Disorder Treatment Guidelines: A 2017 Update

By Flavio Guzman, MD This page offers direct links to the most recent guidelines for the treatment of bipolar disorder. You may notice that we have not included the guidelines published by the American Psychiatric Asssociation, this is because the document has not been updated since 2005. – 2016 – British Association for Psychopharmacology Evidence-based…

Read More

Valproate in Psychiatry: Approved Indications and Off-Label Uses

By Flavio Guzman, MD . This brief article summarizes the clinical uses of valproate in psychiatry. We discuss FDA-approved indications as well as off-label uses. Instead of an exhaustive review, this is a practical summary for clinicians. The term valproate includes a number of formulations, such as: Valproid acid Divalproex sodium Divalproex sodium extended release…

Read More