Antidepressants

Venlafaxine and Desvenlafaxine: Differences and Similarities

Author: Flavio Guzman, MD Venlafaxine (Effexor) is an SNRI that is metabolized to O-desmethylvenlafaxine or desvenlafaxine. In 2008 this active metabolite was approved as antidepressant (Pristiq). In this multimedia tutorial we discuss what the two drugs have in common and their differences, we also explore mechanisms of action, indications, pharmacokinetics, adverse effects and dosing guidelines.…

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Antidepressants and Weight Change: An Evidence-Based Tool

Dent et al [1] conducted a systematic synthesis of the literature to rank the effect of psychotropic drugs on weight change. We summarize and reproduce some of their findings for antidepressant medications. Some key points include: Paroxetine and mirtazapine rank in the first two positions of drug-induced weight gain Tricyclic antidepressants and MAOIs are associated…

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The Psychopharmacology of Bupropion: An Illustrated Overview

Author: Flavio Guzman, MD Bupropion is a norepinephrine dopamine reuptake inhibitor, or NDRI. It is approved as antidepressant as well as for smoking cessation. Some characteristic aspects of its side effects profile include a lack of sexual side effects, compared to other antidepressants and an increased risk of seizures. This presentation reviews the essential aspects…

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Adverse Effects of SSRIs

Author: Flavio Guzman, MD The video below is a brief (length 2:30) overview on the adverse effects of SSRIs. Contents: General concepts Gastrointestinal side effects CNS adverse effects: Basal ganglia Mental effects Sexual dysfunction Download Video Transcript Hello, this is Dr. Flavio Guzman, I´m the editor of Psychopharmacology Institute. In this short video I’m going…

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Mechanism of Action of SSRIs

Author: Flavio Guzman, MD The video below discusses the role of 5HT1A receptors in the mechanism of action of selective serotonin reuptake inhibitors (SSRIs). Transcript Introduction Slide 1  In the next slides we’ll be discussing the mechanism of action of selective serotonin reuptake inhibitors, or SSRIs. Slide 2 This presentation can be divided into three…

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